The six major effects of ginseng on the cardiovascular system

The six major effects of ginseng on the cardiovascular system

1.Effect on blood vessels

The effect of ginseng on blood vessels is generally considered to be a vasodilator, but there are also reports of small dose contraction, large dose expansion or first contraction and expansion. The effect of ginseng on blood vessels varies depending on the type of blood vessel or the state of the body. It has an expanding effect on the whole coronary artery, cerebrovascular, and fundus vessels. Intravenous total saponin can reduce blood vessel and cerebrovascular resistance in hind limbs of animals, but it can increase renal vascular resistance in rats.

2. Effects on cardiac function

The effect of ginseng on the heart is similar to that of the strong heart: there is the effect of first excitement, inhibition, small amount of excitement, and a large amount of inhibition. Experiments have shown that the alcohol extract of red ginseng and the effect of water immersion are mainly to directly excite the myocardium. Acute circulatory failure (slow heart rate, weak heart) caused by a large number of blood loss, ginseng can increase the heart rate abnormally, and the heart rate increases significantly. Ginsenoside has a strong anti-arrhythmia effect and has a strong corrective effect on the tachycardia produced, which can restore the heart rate to a normal level.

3. The effect on blood pressure

In normal or high blood pressure, ginseng has the effect of lowering blood pressure, but there are also examples of raising blood pressure. The blood pressure of ginseng during anesthesia is reduced by small doses and large doses. The amount of treatment has no significant effect on the patient's blood pressure. The boosting effect of ginseng may be related to the shrinkage of kidney and spleen and the contraction of visceral blood vessels. The blood pressure is due to the release of histamine. Anesthetized dogs have rapid tolerance to the antihypertensive effect of ginseng. However, its effect on blood pressure is not affected by atropine, diphenhydramine, phenazoline and propranolol.

4. Effect on hypoxia tolerance

Ginseng or its extract can significantly improve the ability of animals to resist hypoxia, slow down the rate of oxygen consumption, prolong the survival time, and prolong the contraction time of the atrium under hypoxic conditions. Red ginseng has better ability to resist hypoxia than raw sun. Ginseng fruit saponin can significantly reduce the oxygen consumption of animals, enhance the tolerance of mice under hypobaric and hypobaric conditions, and prolong the survival time of mice with cerebral circulatory hypoxia and tissue toxic hypoxia. Consistent with the role of ginseng roots. Ginseng has the effect of reducing myocardial oxygen consumption or increasing coronary blood flow; ginseng total saponin can prevent anaerobic glycolysis and promote glycogen synthesis in hypoxia-deficient cardiomyocytes, while protecting hypoxic and hypoglycemic cardiomyocytes effect.

5. The effect on the myocardium

Ginseng has a protective effect on the myocardium. Ginsenosides can reduce the lactic acid content of the brain and heart muscle under severe hypoxia, and have the effect of protecting myocardial capillary endothelial cells and alleviating mitochondrial damage. The saponins extracted from the stems and leaves of ginseng, the head, the head and the main roots have obvious myocardial protection against myocardial necrosis caused by isoproterenol, which can reduce the damage, especially the effect of ginseng and fruit saponin; The saponins in different parts of ginseng have similar effects to the heart. Ginseng saponin total saponin has a certain protective effect on cardiomyocytes cultured by hypoxia and hypoxia injury. Studies have shown that the mechanism of ginseng total saponin against myocardial ischemia and reperfusion injury is to promote myocardial production and release of prostaglandins, inhibit the production of thromboxane A2, and protect cardiomyocytes by anti-oxygen free radicals and anti-lipid peroxidation. .

6. Effects on hematopoietic function

Ginseng or its extract has protective and stimulating effects on the hematopoietic function of bone marrow, which can increase the number of red blood cells, white blood cells and hemoglobin in normal and anemia animals, and increase the number of red blood cells, hemoglobin and platelets in anemia patients. When peripheral blood cells are reduced or bone marrow is inhibited, the effect of ginseng increasing the number of peripheral blood cells is more pronounced. Ginseng promotes mitosis and stimulates hematopoietic function by increasing the synthesis of bone marrow DNA, RNA, protein and lipids.